@Article{WacheskHuCoTaVaCoTr:2022:SyCVDi,
               author = "Wachesk, Cristiane da Costa and Hurtado, Carolina R. and Correia, 
                         Rebeca Falc{\~a}o Borja de Oliveira and Tada, Dayane Batista and 
                         Vasconcelos, Get{\'u}lio de and Corat, Evaldo Jos{\'e} and 
                         Trava-Airoldi, Vladimir Jesus",
          affiliation = "{Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)} and 
                         {Universidade Federal de S{\~a}o Paulo (UNIFESP)} and {Instituto 
                         de Estudos Avan{\c{c}}ados (IEAv)} and {Instituto Nacional de 
                         Pesquisas Espaciais (INPE)} and {Instituto Nacional de Pesquisas 
                         Espaciais (INPE)}",
                title = "Synthesis of CVD Diamond Nanoparticles and Cytotoxicity Evaluation 
                         in Murine Metastatic Melanoma Cells",
              journal = "Biomedical: Journal of Scientific and Technical Research",
                 year = "2022",
               volume = "41",
               number = "3",
                pages = "32695",
             keywords = "Nano part{\'{\i}}culas, Diamante-CVD, Melanoma Cells, 
                         citotoxicidade, Murine.",
             abstract = "Diamond nanoparticles (DNPs) have demonstrated in vitro and in 
                         vivo biomedical applicability due to their low toxicity and 
                         biocompatibility. Recent studies have focused on the potential use 
                         of DNPs as suitable vehicles to improve drug delivery in cancer 
                         treatment. The advantages of DNPs lie in their high stability and 
                         small size compared to other carbon-based nanomaterials. In this 
                         work, CVD-diamond nanoparticles (CVDDNPs) were synthesized and 
                         evaluated for their application as a new drug delivery platform 
                         for metastatic melanoma therapy. A new synthesis technique 
                         developed DNPs from CVD diamond thin film. This type of diamond 
                         has the same physical and chemical properties as a natural 
                         diamond: extreme hardness, excellent thermal conductivity, low 
                         coefficient of friction, biocompatibility, and is chemically inert 
                         at temperatures below 800 °C. The main objective of this study was 
                         to produce CVD-DNPs by laser ablation and evaluate their 
                         cytotoxicity. A pulsed, ytterbium-doped fiber (Yb) was used to 
                         form DNPs in pure aqueous medium (Milli-Q). The final suspension 
                         was obtained at high concentration of the CVD-DNPs and was used to 
                         evaluate the cytotoxicity in murine metastatic melanoma B16-F10 
                         cells by using colorimetric assays. The characterization by FT-IR, 
                         X-Ray, DLS, RAMAN, SEM, and TEM demonstrated the successful 
                         synthesis of CVD-DNPs with a hydrodynamic diameter of 57 and 54 
                         nm. In vitro studies performed for 24 h and 48 h resulted in 7080% 
                         viability of cells incubated with CVD-DNPs at 250 \μg/mL, 
                         which demonstrated an insignificant cytotoxic effect. Thus, these 
                         results suggest the potential use of CVD-DNPs as a drug delivery 
                         platform for antitumoral therapy.",
                 issn = "2574-1241",
                label = "lattes: 3455204481678421 7 WacheskHuCoTaVaCoTr:2022:SyCVDi",
             language = "en",
           targetfile = "BJSTR.MS.ID.006604.pdf",
        urlaccessdate = "13 maio 2024"
}